As an Actress, Mastandrea has played a number of television roles. After minor roles, Katlin gained critical acclaim in the role of Izzy in the short film Make Believer. For her performance, she was bestowed a Best Young Actress Performance in a Short Film award at the 32nd Young Artist Awards. That same year, Mastandrea had a well-received role on the CBS drama Criminal Minds. Within a year, she was cast in the role of "Weird Ashley" for the ABC sitcom The Middle. as well as the recurring role of "Olivia" in the FX comedy Anger Management.