After gaining experience in community theatre, Chow got her first television role in 2005 where she played the recurring role of Gigi Silveri on One Tree Hill at the age of 13 appearing on the show until 2009.
In 2008, she guest starred on The Suite Life of Zack & Cody. She also co-starred in the Disney Channel original film, Den Brother.
From 2010 to 2013, Chow co-starred as Mikayla on Disney XD original series, Pair of Kings.
In 2012, Chow had a small part in The Amazing Spider-Man, and was later cast in the feature film Run.
In 2014, she was cast in the Fox drama Hieroglyph. However, the series was cancelled before it premiered.
She co-starred in the music video for Hayley Kiyoko's song "Girls Like Girls". Kelsey appeared in the recurring role of Tracy Stewart on season 5, part 1 of Teen Wolf, which premiered on June 29, 2015 and reassumed her role for part 2, which premiered on January 5, 2016.
For all of her work up through 2017 she has used the name Kelsey Chow. For Wind River and Yellowstone, where she played Native American women, she used the name Kelsey Asbille.
