Poindexter is currently best known for his role in 2003's S.W.A.T., where he played by-the-book LAPD Captain Tom Fuller, who went head to head with Samuel Jackson's character Hondo. Daytime audiences know him best from ABC soap opera General Hospital as the not-so-good Dr. Asher Thomas from June 3, 2005, until August 8, 2005, when his character was shot and killed by Jason Morgan (Steve Burton) after he murdered A.J. Quartermaine (Billy Warlock) and Rachel Adair (Amy Grabow). His Asher Thomas character was controversial, as his backstory was a retcon of Jason and A.J.'s history. He was also a recurring character on JAG, as the lawyer/love interest of Major Sarah MacKenzie (Catherine Bell) in Season 3.