In 2001, Ho took over the loss making company Melco International Development Limited. Melco has transformed and re-shuffled the Business focus on to leisure and entertainment. Melco has developed its first casino hotel in Taipa, Macau (now known as Altira Macau, a Forbes 5-Star hotel), the acquisition of one of the only six Macau Gaming concessionaires and sub-concessionaries, and forming a joint venture (now known as Melco Crown Entertainment) with the Australia Billionaire, James Packer’s, Crown Limited (formerly Publishing and Broadcasting Ltd), for Asian gambling Business opportunities. In 2006, Melco Crown Entertainment was publicly listed on NASDAQ (ticker symbol: MPEL) and was the fourth-largest IPO in the US and the then largest ever NASDAQ IPO for an Asian company.