Grand Theft Auto III (2001) was Lazlow’s first appearance in the game in which he produced, scripted and hosted the popular Chatterbox FM radio station. He co-wrote all of the radio stations with Dan Houser and Sam Houser of Rockstar Games. He is mentioned in the MC Hawking song "GTA3" (about the video game) with the line "Sometimes I sit in my car and just Listen to Lazlow / Rock the Chatterbox with the serious flow."
After the massive success of Grand Theft Auto III, Lazlow took a larger role in Grand Theft Auto: Vice City (2002). Rockstar Games hired Lazlow's production company, Radio Lazlow, to co-write and produce all the radio stations in Vice City as well as minor character and bystander scripting. In this game, which takes place in 1986, Lazlow is the host of Vice City radio station V-Rock. In this fictional universe, Lazlow had mentioned in III (which is set in 2001) that he used to host the rock station before he was kicked off.
In Grand Theft Auto: San Andreas (2004), Lazlow also co-wrote and produced all of the in-game radio, as well as hosting Entertaining America on WCTR after the original host Billy Dexter was killed by game character Jack Howitzer on air.
Lazlow "returned" as host of Grand Theft Auto: Liberty City Stories's (2005) rendition of the Chatterbox radio show, although in a much smaller role as the in-game chronology (which takes place in 1998) has Chatterbox as merely a show on a channel, not an entire channel on its own. During his show on the Public Access station, he hints that he will be getting his own channel during a call that frustrates him, when he says that "My buddy Donald (Donald Love) and I have big plans for this station. C-box 24/7!"
Lazlow "returned" in Grand Theft Auto: Vice City Stories (2006), which is set in 1984, as an intern at V-Rock working for his real life friend, Couzin Ed. Earlier in Lazlow's and Couzin Ed's real-life radio careers, Lazlow was the sidekick of Couzin Ed, who he would almost always tease on the radio.
Lazlow is the host of radio station Integrity 2.0 in Grand Theft Auto IV (2008) and Grand Theft Auto: Episodes from Liberty City (2009). Integrity's sole program consists of Lazlow's on-site reporting from around Liberty City. The content of this show is noticeably more profane than previous installments, with the character Lazlow's justification being that he's "fed up with the system." Lazlow also provides the ZiT! Service, where listeners can request the Artist and title of the song currently playing on the radio. Lazlow is also credited among others for creating the conversations of pedestrians in Liberty City. He has an in-game Criminal record, as can be seen in the Liberty City Police Department database.
On 15 September 2013, Lazlow presented a special radio show alongside Pete Donaldson on Absolute Radio in the United Kingdom to celebrate the launch of Grand Theft Auto V. He confirmed that he had been working on the game for the last five years. He appears in the game as a co-host of the talk radio show called "Chattersphere" and the host of the TV talent competition Fame or Shame. He makes his first on-screen appearance in the series in the mission "Fame or Shame" in which he is chased and threatened by protagonists Michael De Santa and Trevor Philips. He also appears in person in other missions, including one in which Michael physically assaults him.
