Lily Safra supports numerous foundations, organizations, and charities. In 1977 she, her husband Edmond Safra, and Nina Weiner founded the International Sephardic Education Foundation. She chairs The Edmond J. Safra Foundation which supports medical research and humanitarian relief. The Edmond J. Safra Foundation Center for Ethics has been established at Harvard; most recently she donated over $12 million to create a cross-disciplinary research laboratory on institutional corruption.