She played Annie Whitman on ABC's Life as We Know It. Darr's previous television appearances include the 1991 short-lived sitcom Flesh 'n' Blood as Rachel Brennan, The WB's teenage drama Popular as Jane McPherson, as well as the short-lived but critically acclaimed 1996 Fox series Profit as Gail Koner. In the fifth season of the sitcom Ellen, she played Laurie Manning, the girlfriend of the title character Ellen Morgan; In "Four for the Seasaw", an epsidode of Frasier, she and Megan Mullally played love interests for the Crane brothers. She played archaeologist Ginny Will on an episode of Quantum Leap.
Her film work includes the Oscar-award-winning Gods and Monsters (1998), in which she appeared as Dana Boone (the wife of Brendan Fraser's character), Pomegranate (2005), as Julia (the mother of Leah Pipes's character) in the soccer film Her Best Move (2006), National Lampoon's Bag Boy (2007), and This Is 40 (2012).
Darr also made an appearance on the Fox drama House in 2006, playing a victim's mother in the episode "Distractions". She has made an appearance on the third season of The Office in the episode "Product Recall". Darr appeared in the fourth season of Weeds (on Showtime) as Ann Carilli. She also made a guest appearance in Nip/Tuck.
