She is perhaps best known for the roles of the high-elf Deedlit in Record of Lodoss War, Lina Inverse in Slayers, Tony Tony Chopper in the 4Kids dub of One Piece, and Serenity Wheeler in Yu-Gi-Oh!. Her best-known role was Amy Rose in Sonic X, and Sonic the Hedgehog from 2005-2009. Living in New York City and frequently meeting people who speak other languages, Ortiz helps in creating the dialect voices for which she is well recognized. Ortiz holds a BFA in theatre from Hofstra University. She has appeared in titles for NYAV Post, 4Kids Entertainment, Central Park Media, Headline Studios, TAJ Productions, and DuArt Film and Video. At the 2002 Katsucon in National Harbor, Maryland, Lisa admitted that her start in voice overs came from her brother stealing her car, which led to series of adventures that led her to meeting a friend to retrieve the car, who then invited her to a casting call for Record of Lodoss War.