Later in 1977, Peluso debuted on daytime television as Wendy Wilkins on Search for Tomorrow, a role she played until the series ended in 1986. Peluso replaced Andrea McArdle who vacated the role to star in the Broadway musical Annie. While playing "Wendy", a sixteen-year-old Peluso received her first on-screen kiss from Kevin Bacon.
Other important soap credentials include her portrayal of "Ava Rescott Masters" on Loving (1988–1995), as well as her portrayal of Lila Hart Roberts Cory Winthrop on Another World (1997–1999) and continued the character on As the World Turns (1999). She has also appeared twice on the ABC soap opera One Life to Live, first as "Billie Giordano" from 1987 to 1988, then as "Gina Russo" in 2001.
Peluso was featured on a 2002 episode of the TLC Network series A Baby Story, chronicling her pregnancy and the birth of her second child, Parker. She and her husband, Photographer Brad Guice, also have a daughter, Phoebe, who shares the same birthday (July 29) as Lisa.
