Since the mid-1990s she has amassed a number of music video credits directing videos for Alanis Morissette, U2, Megadeth, Avril Lavigne, John Mayer, Celine Dion, R.E.M., 3 Doors Down and among other artists. In 2006, she directed her first feature film Take the Lead starring Antonio Banderas. Beginning in 2008, Friedlander moved on to television, directing episodes of One Tree Hill, The Vampire Diaries, Privileged, Pretty Little Liars, 90210, Melrose Place, Outlaw and Gossip Girl.