Nye's parents were both Yiddish speaking Jews from the Russian Empire. They emigrated to the United States in 1906, and became naturalized citizens in 1911. His father owned a small grocery store, which his wife helped him run. Louis Nye attended Weaver High School, but he was not a good student. "My marks were so low," he explained, "that they wouldn't let me in the drama club. So I went down to WTIC Radio, auditioned, and got on a show."
He was born Louis Neistat in Hartford, Connecticut, son of Joseph Neistat and Jennie Sherman. His sister Rose Neistat was born in 1917. Although Nye, who pronounced his given name as Louie, later claimed he was born in 1922, he is listed as age six in the 1920 Hartford County, Connecticut, Federal Census.
Nye lived in Pacific Palisades with his wife, pianist-songwriter Anita Leonard, who wrote the standard, "A Sunday Kind of Love." Married since the late 1940s, they had a son, Artist Peter Nye. Nye was also the great uncle of filmmakers Casey Neistat and Van Neistat and stuntman Dean Neistat.
Nye played dentist Delbert Gray on several episodes of The Ann Sothern Show from 1960 to 1961, the romantic interest of Olive Smith, played by Ann Tyrrell (1909–1983). Nye also played Sonny Drysdale, the spoiled rich stepson of the banker, Milburn Drysdale, on CBS's The Beverly Hillbillies during the 1962 season. He did six episodes, and received more mail than from anything else he had ever done on television, but the character was dropped. It was rumored that someone in the CBS network, or a sponsor, thought Sonny was too "sissified". However, Nye revived the character briefly during the 1966 season.
Nye was a member of the cast of the situation comedy Needles and Pins, playing Harry Karp. The sitcom, which starred Norman Fell, ran for 14 episodes in the autumn of 1973.
Nye never retired. He completed a 24-city tour of the country for Columbia Artists, ending the tour with a two-week stint at the Sahara in Las Vegas. At age 92, he continued to work, appearing in his recurring role of Jeff Greene's father on HBO's Curb Your Enthusiasm from 2000 to 2005.
He earned his greatest fame as a regular on The Steve Allen Show, performing with Allen, Don Knotts, Tom Poston, Pat Harrington Jr., Dayton Allen, Gabriel Dell and Bill Dana. He primarily played urbane, wealthy—and often fey—bon vivants; as part of the weekly "Man on the Street" sketches, his characterization of the pretentious country-club braggart Gordon Hathaway, with his catchphrase, "Hi-ho, Steverino," plus Allen's inability to resist bursting into hysterical laughter at his ad-libs, made Nye one of the favorites on Allen's show. When production moved to Los Angeles, Nye went too and became a character actor in Hollywood.
