Durack has played the roles of Peggy Sawyer in 42nd Street, Miss Dorothy in the Australian Premiere of Thoroughly Modern Millie, Lois Lane/Bianca in Kiss Me, Kate, Rikki Rose in Respect, Sybil Chase in Noël Coward's Private Lives, and Laurey in Oklahoma!.
Durack is known for playing the role of Glinda in the Australian production of Wicked. After previews began in June 2008, the show opened on 12 July at the Regent Theatre in Melbourne. It closed on 9 August 2009, and transferred to the Capitol Theatre in Sydney, where it ran from 5 September 2009 through 26 September 2010. After a short break, Durack began performances on the show's Australian National Tour which began 25 January 2011 in Brisbane (running to 2 April). It moved to Adelaide from 14 April to 4 June 2011, and played Perth from 19 June through 11 September 2011. She has co-starred alongside Amanda Harrison, Jemma Rix, Pippa Grandison, Maggie Kirkpatrick, Bert Newton, Rob Guest, Rob Mills and Anthony Callea.
At the end of the Australian tour of Wicked which took place on 11 September 2011 in Perth, Durack moved on from her four-year role of Glinda to Melbourne for rehearsal of the new Australian production of Strange Bedfellows, where she played the role of the mayor's daughter, Faith. Durack passed the role of Glinda onto Suzie Mathers. When Wicked returned to Australia in 2014, Durack once again played the role of Glinda beginning with the Melbourne season in May 2014.
Durack's debut self-titled album was released on 28 September 2012. Beginning 2017, Durack portrays Glinda the Good Witch in the Australian tour of The Wizard of Oz.
Durack completed filming the role of Katie Morgan in the film Now Add Honey in September 2013 playing the fiancee of Hamish Blake and sister of Portia De Rossi.
While regularly performing in concert with various orchestras throughout Australia, Durack’s cabaret appearances include Immaculate Confection with collaborator Matthew Lee Robinson which toured to Sydney, Melbourne, Perth, Tasmania and the Adelaide Cabaret Festival, All Star Cabaret for the Sydney Theatre Company, Cavalcade for His Majesty's Theatre, Perth, and the 2003 Sydney Cabaret Convention for which she received the Judges’ Award.
