Born and raised in Brooklyn as a Hasidic Jew, Twersky left the community in 2008 after struggling with his faith. He later met fashion designer Duncan Quinn, becoming a model and a Retail manager for Quinn's store in Los Angeles until taking his first acting role in 2010. By 2012, he was cast in his first leading role, in the film Where Is Joel Baum?
In 2015, he also had a recurring role in the television series Transparent. He appeared in the second season of the HBO show High Maintenance.
In September 2017, he appears as one of the main characters in the Netflix documentary One of Us, where Directors Heidi Ewing and Rachel Grady follow him years after he leaves his Hasidic community in Brooklyn, NY and how he deals with his ostracization.
