Gill graduated from the University of Central Lancashire in 2009 with a BA (Hons) in Acting.
Gill appeared in several theatre productions, before she secured her first television role as Phoebe Jackson (later McQueen) in the Channel 4 soap opera Hollyoaks. Gill had attended a number of auditions for the soap in the past, and she was unsure if the character of Phoebe was right for her, but after a number of callbacks, Gill was given the role. Phoebe was introduced as a homeless teenager and a friend for established character George Smith (Steven Roberts). Gill chose to leave the show in 2015 and Phoebe was killed off as part of the long-running "Gloved Hand Killer" storyline. The following year, Gill had a guest role in the BBC sitcom series Cuckoo, before appearing in Doctors for a five episode arc. Gill played Shazia Amin, a pregnant homeless woman. In 2017, Gill appeared in The Good Karma Hospital, and an episode of Casualty. She also stars in Kay Mellor's BBC drama Love, Lies and Records as Talia, a junior registrar.
In October 2017, the BBC announced that Gill had been cast as a companion in the eleventh series of Doctor Who, and will appear alongside Jodie Whittaker as the Thirteenth Doctor in 2018.
