She appeared in a number of popular television series. Among her first roles was that of defendant Betty Kaster in the 1965 Perry Mason episode, "The Case of the Lover's Gamble." She also appeared on Hazel, Gunsmoke and Ben Casey early in her career.
She appeared in the 1967 Paul Newman film Hombre and the 1969 version of The Italian Job as Michael Caine's girlfriend, as well as Waterhole No. 3 (1967) starring James Coburn. Blye appeared with Coburn again in the 1975 film Hard Times. Her other movie roles included The Sporting Club (1971), Walking Tall: Final Chapter (1977), the third film about the life of Sheriff Buford Pusser, and the horror film, The Entity (1982).
Blye's career took a turn in the late 1970s. Her obituary in the online version of The Telegraph pointed out: "By the end of the decade, however, Maggie Blye was no longer being considered for romantic roles. 'In the space of two years,' she noted, 'I went from playing daughters to mothers.'”
A 1983 article about Blye, distributed by the Newspaper Enterprise Association, contained the comment: "Maggie Blye was supposed to be the next big movie star. She ended up making a string of films that were supposed to be blockbusters but didn't even bust a balloon, much less a block."
Blye appeared in several films in the 2000s, including 2004's Last Goodbye and the 2005 horror comedy The Gingerdead Man.
Blye died on March 24, 2016 from cancer at her home in West Hollywood, California, aged 73. She was survived by one brother, Richard Blye, and one sister, Judy Blye Wilson.
