In 2008, Gastini became a spokeswoman for the Christian Blind Mission.
On 18 December 2009, she made her début in cinema with the film Io e Marilyn (Marilyn and I) directed by Leonardo Pieraccioni, where she played the role of Martha, daughter of Gualtiero Marchesi, who was played by the Director.
In 2010, aged 20, Gastini appeared with Anthony Hopkins and Colin O'Donoghue in the American film The Rite, directed by Mikael Håfström and produced by New Line Cinema and Gastini?s father in Los Angeles.
In 2011, Gastini appeared as Giulia Farnese in the TV series Borgia.
