In 1996, Senreich was employed by Wizard Entertainment, gradually rising to become its editorial Director. In 1996 or 1997, Senreich met Green when the actor, a fan of Wizard magazine, responded enthusiastically to an interview request. With Green, Senreich created in 2000 and 2001 Sweet J Presents, a web-based series of animated shorts presented on screenblast.com. Adult Swim contracted the Robot Chicken series on the basis of these shorts.
Senreich along with Tom Root have created Titan Maximum, a television series on Adult Swim, that premiered on September 27, 2009.
Senreich and Green together run the production company Stoopid Monkey. His Emmy nominations were shared with other key members of the production staff of Robot Chicken, including partner Seth Green, for "Outstanding Animated Program (For Programming Less Than One Hour)" in 2007, 2008, and 2009. Senreich received an Emmy Award for Outstanding Short-Format Animated Program (shared with key members of his production staff) at the 62nd annual Emmy Award ceremony held on August 29, 2010.
