In 1971, she graduated from Washburn High School. Her first film role was a small part as a U.S.O. singer in the 1979 Steven Spielberg comedy 1941 and in the same year she appeared in two minor productions, Fyre and Scavenger Hunt. She was one of the principal performers in the 1980 Alan Parker musical drama Fame, portraying Doris, a naive young acting student. In 1981, she starred in the CBS Afternoon Playhouse episode "Portrait of a Teenage Shoplifter".
Maureen Teefy married Alexander Cassini on May 23, 1982. The couple, now divorced, have one child, Isabella.
She provided the voice of the female robot "host" Chrome on the 1997 HBO horror series Perversions of Science. Other television roles include the made-for-TV films Legs and Disaster at Silo 7. She also guest-starred on TV series including Max Headroom and Mike Hammer, Private Eye. Her acting career developed much more in the theater, singing and dancing in several Broadway musicals. Her last film appearance to date was in the 1997 film Men Seeking Women.
