On November 30, 2015, Williams suffered a concussion in the fourth quarter of a 33–27 victory at the Cleveland Browns. He was unable to play the following week at the Miami Dolphins (Week 13). On January 3, 2016, he caught a season-high sic passes for 53-yards in a 24–16 loss at the Cincinnati Bengals. During the game, Bengals' linebacker Vontaze Burfict blindsided Williams while he was running a route in the end zone on the opposite side of where the actual play was happening. Burfict was fined $50,000 and was heavily scrutinized for leading with the crown of his helmet to Williams' chin and neck. He finished the season with 32 receptions 368 receiving yards and a touchdown in seven starts and 14 games.