De Sousa was nominated for Best Supporting Actress in a Film at the NAACP Image Awards for her performance in The Best Man. Other film credits include 30 Years to Life, Lockdown, Ride, and the short films The Fire This Time and Spark. De Sousa's starring television credits include the short-lived (dropped after seven episodes) Fox series The $treet (2000), Second Time Around (2004–05), and One on One (2002–03).