In 1982, Baxter landed the role of Elyse Keaton, the former flower child matriarch of the Keaton family on the NBC sitcom Family Ties. In 1986, during her time on Family Ties, Baxter garnered critical acclaim for her dramatic performance as Kate Stark in the NBC television movie Kate's Secret, about a seemingly "perfect" suburban housewife and mother who is secretly suffering from bulimia nervosa. Following Family Ties, Baxter (whose marriage to Birney ended in 1989) produced and starred in telefilms. She portrayed a psychopathic kidnapper in The Kissing Place (1990) and was nominated for an Emmy Award for Outstanding Lead Actress in a Miniseries or a Special for her work in A Woman Scorned: The Betty Broderick Story (1992), based on the true story of a divorcée who was convicted of murder in the shooting of her ex-husband and his young wife. For her work on the television film My Breast (1994), she received a special award for public awareness from the National Breast Cancer Coalition. In 1997, Baxter once again played the mother of a character played by Michael J. Fox (who portrayed her son, Alex P. Keaton, on Family Ties), this time in two episodes of Spin City.