In 1990, he played the role of Sam on As the World Turns. Throughout the 1990s he guest starred on L.A. Law, Quantum Leap, Matlock, Roseanne, The X-Files, Step by Step, Cybill, ER, The Drew Carrey Show, Sliders, Diagnosis Murder, and The Pretender. He played a Doctor in the 1998 film I Know What You Did Last Summer.
In the 2000s he appeared on Judging Amy, The West Wing, Crossing Jordan, Cold Case, Boston Legal, Days of Our Lives, 24, Bones and the 2002 film Big Fat Liar.
He played Dr. Franks in seven episodes of CSI: Crime Scene Investigation from 2004-2009.
In 2008, he appeared in six episodes of the Fox drama Prison Break as Gregory White, the boss of T-Bag, while Bagwell was working at the GATE corporation under the name Cole Pfeiffer in order to help secure Scylla.
More recently he guest starred on Breaking Bad, The Good Wife, and Person of Interest and had a small role in the 2013 film The Wolf of Wall Street.
