He holds a degree in Theater and Arts from Northwestern University. In 2000 he changed his surname to "Weston" as there was already a "Michael Rubinstein" in the Screen Actors Guild. He has been married to musician Priscilla Ahn since 2010.
Weston appeared in the fifth season of House as a private investigator named Lucas Douglas hired by Dr. Gregory House; he reappeared in season six. Series creator David Shore planned a spin-off show with Weston's character as the lead in 2008, but the show never went into production.
In 2009, Weston appeared in the Gerard Butler action film Gamer. He made a guest appearance on White Collar and Burn Notice (in which the main character, Michael Westen, has a name very similar to his). In 2012, he starred in the A&E television movie, Coma.
In 2016, he appeared as Harry Houdini in Houdini & Doyle.
