Like his younger brother Mukhriz, Mokhzani is a businessman and had played an active role in United Malays National Organisation (UMNO), and at one time serving as the Youth's Wing treasurer. As of 2006, Mokhzani was an UMNO delegate of one of the constituencies in Kedah, but has since lain dormant in his political activities. In May 2008, he followed his father's footsteps to quit UMNO, after 22 years as a member of the Sungai Layar Hujung branch of UMNO.
