Bloodgood was born in Alliance, Nebraska, on September 20, 1975, but was raised in Anaheim, California. Her father, Shell Bloodgood, is an American of Dutch and Irish descent, and her mother, Sang Cha, is Korean. Her father was stationed in South Korea, where he met her mother.
In 2005, she was ranked No. 99 on Maxim's magazine's Hot 100 list. She subsequently ranked No. 53 in 2006, No. 40 in 2007 and No. 20 in 2009.
In Day Break (2006–2007), she portrayed Rita Shelten, the girlfriend of a detective who is framed for murder and arrested in the span of a day, but continually finds himself reliving that same day. In 2007, Bloodgood starred as Livia Beale in the American science-fiction television series Journeyman on NBC.
In early 2009, she joined the third season of the show Burn Notice in a recurring role as Detective Michelle Paxson.
From 2011 to 2015, she portrayed Dr. Anne Glass in TNT's science fiction series Falling Skies executive produced by Steven Spielberg. In 2012, Bloodgood won the "Special Jury Prize" for dramatic ensemble acting in The Sessions with John Hawkes, Helen Hunt, and william H. Macy.
Bloodgood is married to Grady Hall. On December 15, 2012, Bloodgood gave birth to their first child, daughter Pepper. Their second child, Archie, was born on December 19, 2015.
In 2017 she was added as a series regular to the third season of the medical drama Code Black.
