He received the Nandi Award for the Best Villain in 2007 for Athidhi.
Murli Sharma appeared as Captain Khan in the 2004 Bollywood movie Main Hoon Na alongside Shahrukh Khan. In 2007, he had roles in the Hindi movies Dhol, Dhamaal, Black Friday, and the Telugu movies Athithi and Kanthri. He received a Nandi Award for his dual role of Kaiser/Ajay Shastri in Athithi. In 2008, he made an appearance in the Bollywood film Jaane Tu... Ya Jaane Na and appeared in Golmaal Returns and Sunday.
He received the Nandi Award for the Best Villain in 2007 for Athidhi.
In 2011, Sharma had supporting roles in Singham, Oosaravelli, starring Jr. NTR and Dhoni in Telugu. He continued to work in Hindi and Telugu, and in 2012 he had his first role in a Malayalam film, the commercially successful Karma Yodha. In 2013 he also worked in the Tamil and Marathi film industries.
In 2015, he had larger roles in Gopala Gopala and Bhale Bhale Magadivoy. He also worked in Badlapur, ABCD 2, and the Tamil movie Paayum Puli. In 2016, he appeared in Krishna Gaadi Veera Prema Gaadha, Savithri, Sanam Teri Kasam and Wazir.He also did main role in DJ (Duvvada Jagannatham (2017))
