Well known for her role as Cristina Solano in the Colombian soap opera adaptation of the American series Grey's Anatomy titled A corazon abierto, she has had major roles in telenovelas that include Corazones Blindados, Secretos del paraíso and Tiro de gracia.
From an early age, she showed an interest in acting. At the age of 17, she traveled to London to work as a model to campaign for Levi's brand.
She supports the foundation Niños por un Nuevo Planeta, which helps children who have fallen victim to abuse and sexual violence.
She was 16 years old when her mother died. Natalia has married twice, first with Juan Pablo Durán, a musician and Colombian model, and the second time with Alvaro Gilibert, a professional chef, who she would also divorce. She has children named Mia, Nina and Dante.
She was featured in the music video for Juanes' song "La Camisa Negra."
