Zadegan is of Iranian origin. She was born in Heidelberg, Germany on June 20, 1982 and raised in San Francisco, California, USA. She attended Moreau Catholic High School in Hayward. She later graduated from the University of California, Santa Barbara with a BA degree in Literature. She also studied at the Sorbonne University in Paris.
In 2009, Zadegan appeared in the Persian language stage production of From Satellite with Love "Az Mahvareh Ta Eshgh", touring in the U.S. and Europe.
Zadegan appeared in the 2010 film “Elena Undone” in the title role of Elena Winters for Film McQueen that amassed critical attention at festivals worldwide. That same year she also appeared opposite Michael Sheen and Samuel L. Jackson in the role of Jehan Younger in the Columbia Tri Star psychological thriller, Unthinkable.
Zadegan returned to television to recur as resident villainess Isabel on the NBC series “The Event”. She then took on the series regular role of Dr. Gina Bandari on the 2012 series “Emily Owens M.D.” for the CW, then returned to Fox television as Scarlet Leon, the female lead, opposite Greg Kinnear in the 2014 comedy “Rake”.
In 2015, Zadegan continued to appear in other television roles for series like “Extant”, “Legends” and in a very memorable turn as the Queen of Iran opposite Michael Sheen for Showtime’s critical success “Masters of Sex”.
Later that same year she rounded out the all female-lead cast for Bravo’s first scripted series “Girlfriends Guide to Divorce” in the role of Delia Banai. The show went on to be the first ever to get a whopping 3 season pickup and ran for 5 seasons before premiering its final season in Spring 2018.
