DeHuff landed her first big role in the hit comedy Meet the Parents, in which she played Teri Polo's character's sister, Deborah Byrnes. After Meet the Parents, DeHuff had a regular role in the 2002 TV series The Court and appeared in CSI: Miami, Without a Trace, Dragnet, The Practice, and Monk.
Between 2004 and 2005, DeHuff worked on three feature films. One of these, Unbeatable Harold, her final film which was released posthumously, was directed by her husband.
In the weeks preceding her death, DeHuff checked into two hospitals for respiratory illnesses, and was misdiagnosed both times as having bronchitis. She was sent home and directed to take Tylenol in addition to being prescribed an antibiotic. However, her health worsened. On February 16, 2005, paramedics rushed to her home after she collapsed, gasping for air. She subsequently lost consciousness en route to the hospital. By the time the Doctor discovered her true illness, pneumonia, it was too late. Shortly upon arrival to the facility, she died of the illness at the age of 30.
