In 1995, Scheer became a member of New York City's longest running Off-Broadway comedy show, Chicago City Limits. As a member of their touring company, Scheer extensively traveled throughout the United States as well as overseas.
In 1998, he joined the Upright Citizens Brigade Theatre in New York City where he performed Sketch and Improvisation with Respecto Montalban, winners of the 2003 ECNY Award for "Best Improv Show". The group included Rob Riggle, Rob Huebel, Jack McBrayer and Dannah Feinglass. They performed their brand of long-form improvisation to sold out crowds every Saturday night for over five years and collaborated with Adam McKay on a political Sketch comedy show called George Bush is a Motherfucker.
In 2002, Scheer created and starred in Automatic Vaudeville at the Ars Nova theater, which The Hollywood Reporter called "one of the top five shows in the country".
Scheer lives in Los Angeles and is married to actress-writer June Diane Raphael. They first met in January 2004, after the artistic Director of Manhattan's Upright Citizens Brigade Theatre brought Scheer in to offer tips to Raphael and her comedy partner Casey Wilson on making improvements to their UCB two-woman Sketch show, and started dating shortly afterwards. They moved from New York to Los Angeles in 2005. In October 2009, Scheer and Raphael married at the Santa Barbara Museum of Natural History. Scheer's best man was a Jack Nicholson impersonator. They have two sons, Gus born in April 2014, and Sam, born in August 2016.
Scheer moved to Los Angeles in 2006 and is a regular performer at Upright Citizens Brigade Theatre in Los Angeles (UCBTLA). He performs an improvised show based on audience members' Facebook profiles called FACEBOOK. The show was named the "Best Improv Show" by Los Angeles magazine and has been profiled on Good Morning America. Cast members include McBrayer, Riggle, and Huebel.
Around the summer of 2005, Scheer began collaborating with fellow comedians Rob Huebel and Aziz Ansari as well as Director Jason Woliner to make short films. The first video created by the group was Shutterbugs, about Huebel and Ansari as cut-throat child talent agents. This was followed by the Sketch Illusionators, which starred Ansari and Scheer as Criss Angel-style goth magicians. In mid-2006, MTV gave the green light for a Sketch series from the group, called Human Giant, which debuted April 5, 2007.
The League premiered on FX on October 29, 2009 and ran for seven seasons. The series is a semi-scripted comedy from Jeff and Jackie Marcus Schaffer about a group of friends in a fantasy football league. Scheer plays Dr. Andre Nowzick, a rich plastic surgeon whose naivete makes him the butt of many jokes. Scheer has co-scripted a handful of episodes: "The Anniversary Party", "Expert Witness", "Sober Buddy", "The Out of Towner" and "Tailgate" with co-star Nick Kroll as well as the episodes "Bringer Show" and "The Block".
In 2010, Scheer organized a charity event with Ben Stiller called A Night of 140 Tweets in which he got 140 comedians and actors to appear on stage at the UCB Theater in Los Angeles, each of them reading a single tweet. The performers included Stiller, Will Ferrell, Ashton Kutcher, Demi Moore, Aziz Ansari, the cast of It's Always Sunny in Philadelphia, Dane Cook, Wilmer Valderrama, John Cho, Mindy Kaling, and Sasha Grey. The event, released as a charity DVD and online download, raised over $500,000 dollars for Haiti.
How Did This Get Made? is a podcast on Earwolf hosted by Scheer, June Diane Raphael, and Jason Mantzoukas. Each episode has a Celebrity guest/comedian and features the deconstruction and mockery of terrible films. In 2011, iTunes selected How Did this Get Made? as its favorite comedy podcast of the year. In 2012, LA Weekly named the show "The Best Comedy Podcast". Guests have included Kevin Smith, Damon Lindelof, "Weird" Al Yankovic, Danny Trejo, Vanilla Ice, Adam Scott, Nick Kroll, and Amy Schumer.
Paul Scheer and Jack McBrayer made semi-regular appearances on the Nick Jr. series Yo Gabba Gabba!, during a segment called "Knock Knock Joke of the Day". Scheer and McBrayer were featured as themselves in the Yo Gabba Gabba! comic book, and made appearances on the Yo Gabba Gabba! live tour. In 2012, Scheer appeared as a villainous Cowboy Android in an episode of The Aquabats! Super Show!, another series from the creators of Yo Gabba Gabba!
In 2013, upon the return of The Arsenio Hall Show, Scheer launched a web series for JASH called The ArScheerio Paul Show. In each episode, Scheer re-creates interviews from Arsenio Hall's original show, including the famous Bill Clinton episode, with Will Arnett playing Clinton. Scheer Sports a comically enlarged flat-top haircut to resemble Hall.
Scheer and Giovanetti continued their collaboration with Marvel Comics where they penned Deadpool Bi-Annual #1 and a Guardians Team Up, which were released September 2014 and 2015.
In September 2015, Scheer said he practices Transcendental Meditation to calm down and be more creative.
In 2016, Scheer created, executive produced, and directed segments for the late-night Sketch comedy series, Party Over Here, for Fox with The Lonely Island which starred Nicole Byer, Alison Rich, and Jessica McKenna.
In 2017, he appeared on Celebrity Family Feud and lost to his wife, June.
Scheer is most known as a star of the FX/FXX series The League and as the co-creator and one of the stars of the cult MTV Sketch series Human Giant, as well as the Adult Swim comedy-action-parody series NTSF:SD:SUV::. He co-hosts the popular film discussion podcast How Did This Get Made? alongside his wife June Diane Raphael and Jason Mantzoukas. He is a recurring actor on the HBO comedy Veep and the ABC comedy Fresh Off the Boat. It was recently announced Scheer will helm a TV reboot of Galaxy Quest for Amazon. In 2018, Scheer won a SAG award for his work on Veep.
