Blake received the Montréal World Film Festival Award for Best Actress for her portrayal, in the title role, in the 2014 drama film Melody (2014).
At 13, Blake was cast in a short film. Blake's first film role was in the Australian children's movie Paws. After studying at NIDA, she worked on Australian television shows Home and Away (as Mandy Thomas), Pacific Drive, and Heartbreak High. In 1997, she took the role of Dr Maxine Summers in the ABC crime drama Wildside.
She has also starred in several films, including 2001's Lantana with Anthony LaPaglia, as well as 2003's Perfect Strangers for which she won the Fantasporto Award for Best Actress. Between 2006–2007, she played Hilary Davenport in the British satirical black comedy Suburban Shootout. She played "Belinda" in a British TV movie, Clapham Junction, in 2007. In 2009, she starred in the UKTV mini-series False Witness. She also played a main role in The Prisoner. In 2010, she portrayed Hazel Hawke in the telemovie Hawke.
In 2003, she married Wildside co-star Tony Martin. They later starred together in Serangoon Road.
In 2012, Blake portrayed Kris Perry in the theatre production of 8 in Sydney and Melbourne. In 2013, she portrayed Lady Tuckworth in the HBO Asia series Serangoon Road. She played a main role in the 2014 drama film Melody, for which she has received recognition (see below). She appeared in the 2016 film Gods of Egypt.
Blake received the Montréal World Film Festival Award for Best Actress for her portrayal, in the title role, in the 2014 drama film Melody (2014).
