In 2007, he performed for the first time with his father in the ITV adaptation of A Room with a View playing father and son.
In February 2008, Spall met Actress Elize du Toit; they were married on 14 August 2010 and live in West Kensington, London. They have two children: a daughter Lena, born 2011, and a son Rex, born November 2012.
In 2012, Spall portrayed Canadian author Yann Martel in the Academy Award-winning drama film Life of Pi, directed by Ang Lee and starring Suraj Sharma and Irrfan Khan. The film was a critical and financial success, winning four Academy Awards and making over $600 million at the box office. In 2013, he played the newlywed husband in I Give It a Year, a comedy about the trials and tribulations of a couple during their first year of marriage.
In 2014, Spall appeared in the coming-of-age drama X+Y, alongside Asa Butterfield and Sally Hawkins, and the seasonal family comedy Get Santa. In 2015, he played John Hancock in the History Channel three-part series, Sons of Liberty, alongside Jim Broadbent, and appeared in the Academy Award-winning biographical comedy-drama The Big Short, alongside Christian Bale, Brad Pitt, Ryan Gosling and Steve Carell. Also that year, Spall played Harry Price in Harry Price: Ghost Hunter, ITV's adaptation of Neil Spring's debut novel, The Ghost Hunters. The film aired on ITV1 on 27 December.
In 2016, Spall was due to portray Eli Mills in the fifth installment of Steven Spielberg's Jurassic Park series, with The Impossible Director J. A. Bayona.
