She followed it with appearances in big budget movies such as Dhoom (2004), Kyon Ki (2005), Garam Masala (2005) and Golmaal (2006). Sen also did a cameo in the 2006 film Dhoom 2, and she followed it with Johnny Gaddaar, alongside newcomer actor Neil Nitin Mukesh. In 2008, she appeared in De Taali and in 2009, Sankat City and Horn Ok Pleasse. All three of these films were box office disasters. After these films, her career declined.