He has guest-starred on shows such as Night Court, Kung Fu, Starsky and Hutch, Kojak, The Rockford Files, Baretta, and Sanford and Son; he also had a role in Roots: The Next Generations. He made a memorable appearance in the 1973 film The Mack, as the militant brother of the main character Goldie. He appeared in other blaxploitation films including Hit Man (1972), Sweet Jesus, Preacherman (1973), Darktown Strutters (1975) and The River Niger (1976). His other film credits include McQ (1974) with John Wayne, The Greatest (1977, as Sonny Liston), Semi-Tough (1977), Heart Condition (1990) and Pentathlon (1994). He also starred in Hangin' With Mr. Cooper (1992-1993) as Coach Ricketts in a recurring role with comedian/actor Mark Curry, and in A Thin Line Between Love & Hate (1996) with Martin Lawrence, Bobby Brown, and Lynn Whitfield. He also appeared as a Celebrity guest on The $25,000 Pyramid for a week's worth of shows in June 1985.
Mosley was born in Los Angeles, California. He grew up in the Imperial Courts public housing with his mother Eloise Harris in Watts. In 1974, he founded the Watts Repertory Company.
He appeared in Magnum, P.I. as Tom Selleck's friend and a helicopter pilot who operates his own tourist charter Island Hoppers from 1980-1988. He appeared in season five of Las Vegas as the Billionaire friend of Montecito owner A.J. Cooper (Tom Selleck).
Mosley is a licensed private helicopter pilot in real life, but when on the set of Magnum P.I. he was not allowed to do his own Stunts. A pilot wearing a body stocking with muscles would be used instead. In 2013 at the HAI Heli-Expo in Las Vegas, a ceremony for the restored MD 500D helicopter was held. Both Mosley and fellow Magnum P.I. co-star Larry Manetti autographed the nose of the helicopter.
