Ayres appeared on the BBC One semi-improvised sitcom Outnumbered as Gran in series 3 (2010) for the episodes "The Family Outing" and "The Internet". She returned as Gran in the first episode of series four (2011) named "The Funeral". Ayres also appeared in the Christmas special in 2012.
In addition to her film and television work, in 2011, Ayres provided voice and motion capture work for Katherine Marlowe, the main antagonist of the video game Uncharted 3: Drake's Deception, opposite Nolan North, Richard McGonagle and Graham McTavish, and received rave reviews for her performance.
