Haylock has primarily worked as a costume designer. In 1993, he won a Big Easy Entertainment Award for Best Costume Design for Snow Queen at the age of 17. He has been nominated for 13 Big Easy Entertainment Awards for costume design, winning six. Haylock has also made costumes for New Orleans Opera.
In New Orleans, Haylock started performing as a drag Artist in 1996 in the play Pageant. The local drag queen Lisa Beaumann saw him in the play and later cast him in shows at the nightclub Oz. Haylock won the New Orleans Gay Entertainer of the Year for three years as drag queen Bianca Del Rio.
In 2001, Bianca Del Rio was selected as co-grand marshal, with Pat "Estelle" Ritter and Rick Thomas for Southern Decadence XXIX.
Del Rio was featured in the web series Queens of Drag: NYC by gay.com in 2010. The series featured fellow New York drag queens Dallas DuBois, Hedda Lettuce, Lady Bunny, Mimi Imfurst, Peppermint, and Sherry Vine. In 2011, Del Rio appeared on One Night Stand Up: Dragtastic! NYC by Logo TV. The episode was filmed live at the Bowery Ballroom and was hosted by Pandora Boxx.
He appeared on the cover of Next for their Summer Yearbook 2012 issue. Del Rio appeared on the variety show She's Living for This, hosted by Sherry Vine, in 2012.
In 2013, Del Rio was announced as the lead in the independent film Hurricane Bianca, written and directed by Matt Kugelman. An Indiegogo campaign was created to Finance the film and was sponsored by Fractured Atlas, a non-profit art services organization in New York City; the campaign raised over $30,000. A sequel, Hurricane Bianca: From Russia With Hate, is currently in production.
Following her success on Drag Race, Del Rio has written and toured several stand-up shows, including The Rolodex of Hate (2014), Not Today Satan (2015–16), and Blame It On Bianca Del Rio (2017–present). She has also performed as a host on the Werq the World Tour alongside other Drag Race queens.
