Samantha was born in Adelaide, South Australia. She is the oldest of three children. Her younger siblings are Jess Noble (a journalist), and Dan Noble (an entrepreneur). Their parents are renowned actor John Noble and Penny Noble - who owns a Yoga school. Samantha attended Brigidine College Randwick, (Sydney). She completed her Masters at Sydney University in 2004 and then decided after graduation she wanted to be an Actress. In 2001 Samantha graduated with a BA in Drama, History and Education from the Australian Catholic University and she has trained at NIDA, the Actors Studio in New York, the Stella Adler Institute in Los Angeles, Ivana Chubbick Studio, On Camera Connections and ATYP. She teaches acting at several film schools in Sydney and Los Angeles. She plays the piano, guitar and saxophone, and resides in New York City with her husband and one child.