Sameera was born on 14 December 1980 in Rajahmundry, Andhra Pradesh to a Telugu family. Her father Chinta Poli (C. P.) Reddy is a businessman, while her mother Nakshatra, referred to as Niki by her daughters and in the media, was a microbiologist and worked with an NGO. She has two siblings, Meghna Reddy, a former VJ and supermodel, and Sushama Reddy, a Bollywood Actress and model, both elder to her. She did her schooling at Bombay Scottish School in Mahim, Mumbai and graduated from Sydenham College.
Reddy first appeared in ghazal singer Pankaj Udhas's "Aur Aahista" music video in 1997. Sameera was meant to make her debut as an Actress in Saravana Subbiah's Tamil film Citizen, during early 2000s, but eventually did not feature. She caught the attention of Bollywood and was cast in a pivotal role in the 2002 Hindi film Maine Dil Tujhko Diya. In 2004, she appeared in Musafir, opposite Anil Kapoor, Aditya Pancholi and Koena Mitra.
Sameera Reddy made her film debut with the 2002 film Maine Dil Tujhko Diya. She is best known for starring in films such as Darna Mana Hai (2003), Musafir (2004), Jai Chiranjeeva (2005), Taxi Number 9211 (2006), Ashok (2006), Race (2008), Varanam Aayiram (2008), De Dana Dan (2009), Aakrosh (2010), Vettai (2012) and Tezz (2012).
Reddy was a judge for the Miss Sri Lanka Online contest in 2012.
Reddy got married to Akshai Varde, an Entrepreneur on 21 January 2014. It was a traditional Maharashtrian wedding. They welcomed their son on 24 May 2015.
