Sameera Reddy made her film debut with the 2002 film Maine Dil Tujhko Diya. She is best known for starring in films such as Darna Mana Hai (2003), Musafir (2004), Jai Chiranjeeva (2005), Taxi Number 9211 (2006), Ashok (2006), Race (2008), Varanam Aayiram (2008), De Dana Dan (2009), Aakrosh (2010), Vettai (2012) and Tezz (2012).