Gould was born in Brooklyn, New York. She began acting in films with an uncredited role in T-Men (1947), and was the Phone Operator in Romance on the High Seas (1948), Doris Day's debut film. She appeared in several uncredited roles for the remainder of the decade, and received her first screen credit with The Story of Molly X (1949). During the same decade, Gould enjoyed a four-year run as Miss Duffy, the man-hungry daughter of the forever-unheard owner of radio's Duffy's Tavern.
In 1953, Gould appeared as a guest in an episode of Letter to Loretta with Loretta Young. In 1959 she played a secretary in the Academy Award Winning Movie Imitation of Life with Lana Turner and Juanita Moore. She continued to guest star in the 1950s and 1960s in such television series as I Love Lucy, I Married Joan, December Bride, Maverick, The Flintstones, The Twilight Zone, The Lucy Show, Burke's Law, I Dream of Jeannie, Love, American Style, Gilligan's Island, The Brady Bunch and Mister Ed. She played a prominent supporting role in the film The Ghost and Mr. Chicken in 1966. In 1963, Gould released a comedy single record entitled Hello Melvin (This Is Mama) as an answer to Allan Sherman's hit "Hello Muddah, Hello Fadduh".
Twice married, Gould was the widow of broadcasting executive Larry Berns and television/film Director Hollingsworth Morse. With Berns she had one son, Michael Berns, in 1965.
In September 1966, Gould replaced her friend Alice Pearce, who had been battling ovarian cancer during the second season of the ABC-TV situation comedy Bewitched, and had died in March. The producers were undecided about what to do with the character of Gladys, so at first had Actress Mary Grace Canfield brought in to play Harriet Kravitz, Abner's sister, who would be keeping him company while his wife was visiting her mother. Soon after, Sandra Gould got the role of Mrs. Kravitz when actress-comedian Alice Ghostley turned down the role. (Ironically, a few years later, Ghostley would become a semi-regular on the series playing Esmeralda, a well-meaning but inept witch.)
In the role of Gladys, Gould's over-the-top performance and shrill voice were popular with viewers, and she succeeded ultimately in making the character her own. She remained with the series through its 7th season. The Kravitzes were referenced once in the final/8th season (ep 241 Three Men and a Witch on a Horse) but the characters did not appear. After Bewitched was cancelled in 1972, Gould reprised the role of Gladys five years later in a spin-off of the series, Tabitha. Gould also made appearances on Columbo, The Brady Bunch, Adam-12, Punky Brewster, Friends, and Veronica's Closet.
Gould died on July 20, 1999 in Burbank, California of a stroke following heart surgery, three days before her 83rd birthday.
