Sengbloh has made her screen debut playing opposite Kimberly Elise in the 1997 television film The Ditchdigger's Daughters. In 1999, she made her big screen debut appearing in the independent drama film Funny Valentines starring Alfre Woodard. She later played small parts in films Across the Universe, American Gangster, and well as guest starred on television series include Law & Order and The Good Wife.
Sengbloh has starred in a number of Broadway musicals, including Aida, Wicked, The Color Purple, Hair, Fela!, Motown: The Musical, and Holler If Ya Hear Me. Her breakthrough came in 2015, then Danai Gurira cast Sengbloh in Eclipsed, a play about five Liberian women and their tale of survival near the end of the Second Liberian Civil War. It became the first play with an all-black and female creative cast and team to premiere on Broadway. Eclipsed opened Off-Broadway at The Public Theater in October 2015 with positive reviews and ran until November 2015. The following year, it transferred to Broadway, premiering at the John Golden Theatre with an opening on March 6, 2016. Her performance received positive reviews from critics. She won Drama Desk Award for Outstanding Featured Actress in a Play for original Off-Broadway production, and Tony Award for Best Featured Actress in a Play nomination for Broadway production.
In 2017, Sengbloh was cast in a recurring role as Angela Webster for the sixth season of Shonda Rhimes' political drama Scandal. She also filmed the role of Roberta in the 2018 historical drama film Ask for Jane.
