Rosenberg was born in Needham, Massachusetts. After high school graduation in 1981, he attended Boston University, from which he received his Bachelor's Degree in 1985. He earned his MFA from UCLA. His screenwriting credits include major motion pictures such as Con Air, High Fidelity and Gone in 60 Seconds.
During production of the film Domestic Disturbance in April 2001, Rosenberg was arrested along with actor Vince Vaughn after a bar brawl in Wilmington, North Carolina. The scuffle broke out at the Firebelly Lounge, where actor Steve Buscemi had been stabbed in the face, throat, and arm.
"It was the worst winter ever in this small hometown. Snow plows were coming by, and I was just tired of writing these movies with people getting shot and killed. So I said, 'There is more action going on in my hometown with my friends dealing with the fact that they can't deal with turning 30 or with commitment' – all that became Beautiful Girls."
In October 2015, Rosenberg was brought in to rewrite Jumanji: Welcome to the Jungle with his writing partner Jeff Pinkner. In February 2018, Rosenberg, Pinkner and Director Jake Kasdan were expected to return to the film's sequel.
