Clarke has also appeared in West End theatre. Her roles include General Cartwright in Guys and Dolls (1996), Joanne Jefferson in Rent at the Shaftesbury Theatre (1998), and Miss Sherman in Fame (1999). She played Rafiki in The Lion King from 2000 to 2002 at the Lyceum Theatre and in 2004 played the character of Matron Mama Morton in Chicago.