As of 2006, Sohn was living with her husband, Adam Plack, and daughter, Sophia, 16, who was attending Baltimore School for the Arts. Sohn has another daughter, Sakira, 20, who lived in New York at that time.
Previously involved in political activism (she campaigned in North Carolina in support of Barack Obama's 2008 presidential bid), Sohn took a break from acting in 2009 to concentrate on social issues. She is the founder and CEO of the Baltimore-based reWIRED for Change, an outreach program intended to communicate with (and ultimately rehabilitate) at-risk youth involved in Criminal activity. The program is run out of the University of Maryland School of Social Work and uses episodes of The Wire as a teaching tool, encouraging the participants to examine and query their lives and past actions. Other actors and Writers involved with The Wire serve as board members. In 2011, she was presented with the Woman of the Year award from the Harvard Black Men's Forum.
She had a supporting role in the Hollywood film Step Up 2: The Streets. In 2008-09, she was a guest star in the ABC series Brothers & Sisters, and in 2010 she appeared in an episode of CBS series The Good Wife. In 2011, she was a guest star on the show Bar Karma. She played Detective Samantha Baker in the first two seasons of the medical drama television series Body of Proof with Dana Delany and Jeri Ryan, which premiered on ABC on March 29, 2011.
On May 30, 2014, it was announced that Sohn would be joining season 2 of The Originals, in a recurring role as the witch Lenore a.k.a. Esther Mikaelson.
Sohn made her directorial debut with the 2017 HBO documentary Baltimore Rising about the 2015 Baltimore protests and community organizing that arose in response to police violence.
