Guarino is originally from Orlando, Florida. He is best known for starring as a cast member on The Big Gay Sketch Show for all three seasons. He has appeared in films such as Confessions of a Shopaholic and I Hate Valentine's Day. He has also made guest appearances on shows such as 'Til Death and Law & Order: SVU. Guarino has performed Sketch comedy as a member of "Sak Comedy Lab" in Orlando and with The Groundlings in Los Angeles, and co-starred in The Nuclear Family, a fully improvised Off-Broadway musical comedy that debuted in 2005. He also appeared in the 2008 film The Clique as an art Teacher. He currently stars in the web series EastSiders.