On television, Wisdom played Tom Ferguson in the long-running soap Coronation Street (1999–2000), Ivor Claire in the Evelyn Waugh adaptation Sword of Honour (2001), Stephen Clarke in the thriller Suspicion (2003) and Marco Bailey in Sky One's airline drama Mile High (2003–04). Other television work includes Harry Enfield's Brand Spanking New Show, Children of the New Forest, Wycliffe and Blackhearts in Battersea. In early 2010, Wisdom starred in an episode of Agatha Christie's Poirot. He had a one-episode guest role in NBC's Hannibal as Antony Dimmond in 2015. Wisdom also starred as the archangel Michael in SyFy Channel's Dominion, which began airing in June 2014 and was renewed for a second season which concluded on 1 October 2015.