In 2017, transgender actors and actresses including Lysette (with the help of GLAAD and ScreenCrush) were part of a filmed letter to Hollywood written by Jen Richards, asking for more and improved roles for transgender people.
Before becoming an Actress, Lysette had experience in the sex work industry. In an interview with The A.V. Club, she spoke about her experiences, stating "In the past, I’ve talked about my experience with survival sex work, and also with dancing in gentleman’s clubs to pay for acting classes and make all my auditions when I was pounding the pavement all those years in New York City."
