Caplan played the Home Economics Teacher in the television series Fast Times, with Courtney Thorne-Smith, Patrick Dempsey, and Wallace Langham. In The New Homemakers guide. (1988), Caplan played against Ronald Reagan Jr.; she worked with Bonnie Hunt as the nosey neighbor duo living next door to Demi Moore and Judge Reinhold.
In the 1989 box office hit Look Who's Talking, Caplan played the flirty best friend of Kirstie Alley, the female lead. She returned as Rona in the moderately successful first sequel Look Who's Talking Too (1990), with Elias Koteas as her love interest. She (and Koteas) declined to appear in the financially unsuccessful second sequel Look Who's Talking Now (1993).
Caplan was born in Pittsburgh, Pennsylvania. She is probably best known for her role as Miss Geist in the 1995 box office hit Clueless, which starred Alicia Silverstone. Caplan went on to Executive Produce and reprise the role of Miss Geist in the ABC TV series Clueless.
At Sony Pictures Entertainment in 2000, Caplan produced Loser, starring Jason Biggs and Mena Suvari. Caplan played Suvari's character's best friend, Gena, a strip bar worker.
Caplan has also played B. Lawney, a waitress with Richard Gere in The Flock (2007), directed by Andrew Lau; Mary Benett, a hard-edged bus driver for CSI: Crime Scene Investigation; and a past-her-prime movie star desperate for a comeback in Secrets of a Hollywood Nurse. Caplan appeared as Harry Dean Stanton's wife in 9 Full Moons (2013).
Caplan played the dance Teacher in the television series Community in season 1 episode 14 entitled "Interpretive Dance" (2010). She also appeared in the "Quantum Leap" episode "Thou Shalt Not..." in 1989.
In 2012, Caplan appeared as "Katie" in Tim and Eric's Billion Dollar Movie, with Tim Heidecker, Eric Wareheim, John C. Reilly, Will Ferrell, and Zach Galifianakis.
