To English-speaking audiences, Mühe was probably best known for portraying Hauptmann (Captain) Gerd Wiesler in Florian Henckel von Donnersmarck's Das Leben der Anderen (The Lives of Others, 2006), which won the Academy Award for Best Foreign Language Film in 2007. The film is set in the mid-1980s, and Wiesler is a Stasi agent who is assigned to bug and conduct surveillance of the apartment of an East German Playwright, Georg Dreyman (Sebastian Koch), and his girlfriend, the Actress Christa-Maria Sieland (Martina Gedeck). However, he becomes disillusioned about the necessity of monitoring the couple for national security reasons after discovering that the government minister who ordered the surveillance did so for sexual rather than political motives. Gradually, Wiesler's heart moves from contempt and envy to compassion. For his performance, in 2006 Mühe received, among other things, the Beste darstellerische Leistung – Männliche Hauptrolle (Best Performance by an Actor in a Leading Role), Gold, at Germany's most prestigious film awards, the Deutscher Filmpreis (German Film Awards); and the Best Actor Award at the European Film Awards.