Watson-Johnson played Blue's love interest in the 1972 film Trick Baby. She was also a regular cast member of the 1985-86 situation comedy Foley Square as Denise Willums, the secretary for Alex Harrigan, played by the show's star, Margaret Colin. She played a small role on Sister, Sister as Lisa's (Jackée Harry) best friend Patrice, and as the mayor's secretary, Lucille Banks, on Carter Country. She also had a recurring role as "Birdie" on The Young and the Restless. In 2005, she appeared in the film Christmas with the Kranks. In addition, Watson-Johnson has made appearances in episodes of television shows as The Love Boat, Hill Street Blues, Married... with Children, L.A. Law, Suddenly Susan, Dharma & Greg, The X-Files, ER, Days of Our Lives, Malcolm in the Middle, CSI: Crime Scene Investigation, Desperate Housewives, Ghost Whisperer, Benson, The Big Bang Theory, Good Times, Dexter, Two and a Half Men, Southland, Criminal Minds, A.N.T. Farm, What's Happening!! and several other series.
Watson-Johnson has been married twice. Her first marriage was to Joe Duckett from 1976 until 1977, and was last married to Photographer Van Johnson from 1979 to 1991. Watson-Johnson has a daughter name Sunde Jinia Johnson (b. 1983) with Johnson. In 2005, Watson-Johnson was a witness in Michael Jackson's second case of child molestation.
As a voice Actress, she has been tied to Hanna-Barbera Productions and Warner Bros. Animation with roles in shows such as Captain Caveman and the Teen Angels, Laff-A-Lympics, A Pup Named Scooby-Doo, Animaniacs, Batman: The Animated Series, Superman: The Animated Series and Batman Beyond, as well as the feature film The Ant Bully, and several video games related to these productions. From 1991 to 1992, she lent her voice to the show Baby Talk, where she was the voice of baby Danielle (played by Alicia and Celicia Johnson). In 2006, Watson-Johnson had roles in three films: The Ant Bully, The Celestine Prophecy and Garfield: A Tale of Two Kitties. In 2017, Watson-Johnson was cast as Stella on the soap opera General Hospital, aunt of Donnell Turner's character Curtis Ashford.
