Lamb was born in Los Angeles, California, United States and attended Los Angeles High School. First admitted in 1930, he received a Bachelor of Science in Chemistry from the University of California, Berkeley in 1934. For theoretical work on scattering of neutrons by a crystal, guided by J. Robert Oppenheimer, he received the Ph.D. in physics in 1938. Because of limited computational methods available at the time, this research narrowly missed revealing the Mössbauer Effect, 19 years before its recognition by Mössbauer. He worked on nuclear theory, laser physics, and verifying quantum mechanics.